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POST-SYNTHETIC CHEMICAL MODIFICATION OF RNA AT THE 2'-POSITION OF THE RIBOSE RING VIA 'CLICK' CHEMISTRY
POST-SYNTHETIC CHEMICAL MODIFICATION OF RNA AT THE 2'-POSITION OF THE RIBOSE RING VIA 'CLICK' CHEMISTRY
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机译:通过“单击”化学对核糖环2'位置进行RNA的合成后化学修饰
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摘要
This invention relates to a 2′-modified RNA agent comprising at least one RNA strand containing a 2′-O substituent having an alkyne functional group attaching to the O atom at the 2′-position on one or more ribose rings, wherein the 2′-O substituent is located at one or more of positions 2, 3, 4, 7, 8, 9, 10, 11, 13, 14, and 16, from 5′-end of the RNA strand. This invention also relates to a 2′-modified RNA agent comprising at least one RNA strand containing a 2′-O substituent having a triazole functional group attaching to the O atom at the 2′-position on one or more ribose rings, wherein the 2′-O substituent is located at one or more of positions 2, 3, 4, 7, 8, 9, 10, 11, 13, 14, and 16, from 5′-end of the RNA strand.
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