Substituted furo3,2-cpyridines, thieno3,2-cpyridines, thieno2,3-dpyridazines and pyrido3,4-dpyridazines as phosphodiesterase type 10A inhibitors

摘要

The present invention relates to novel compounds of the formula I which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.; wherein Q is O or S, X¹ is N or CH, X² is N or C—R⁷; X³ is O, S—X⁴═C(R⁸)—, where C(R⁸) is bound to the carbon atom which carries R², or —X⁵═C(R⁹)—, where X⁵ is bound to the carbon atom which carries R²; X⁴ is N or C—R⁹; X⁵ is N; Het is selected from optionally substituted phenyl, monocyclic hetaryl and fused bicyclic hetaryl; R¹ is selected inter alia from hydrogen, halogen, OH, C₁-C₄-alkyl, trimethylsilyl, C₁-C₄-alkylsulfanyl, C₁-C₄-alkoxy-C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-alkoxy-C₁-C₄-alkoxy, the moiety Y¹-Cyc¹; R² is selected inter alia from hydrogen, halogen, OH, C₁-C₄-alkyl, trimethylsilyl, C₁-C₄-alkoxy-C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-alkoxy-C₁-C₄-alkoxy, C₂-C₄-alkenyloxy, etc; A represents one of the following groups A¹, A², A³, A⁴ or A⁵: ; where * indicates the points of attachment to Het and to the nitrogen atom, respectively; and where R³ to R⁹, R^3e, R^3f, A′, Y¹ and Cyc¹ are defined in the claims.