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Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
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机译:基质细胞衍生因子-1的蛋白酶抗性突变体在组织损伤修复中的作用
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摘要
The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-1 to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.
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