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Enhanced generation of cytotoxic T-lymphocytes by IL-21 mediated FOXP3 suppression
Enhanced generation of cytotoxic T-lymphocytes by IL-21 mediated FOXP3 suppression
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机译:IL-21介导的FOXP3抑制作用增强细胞毒性T淋巴细胞的产生
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摘要
A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount is described. In the method, the CTL preparation is preferably administered as a preparation of an in vitro antigen-stimulated and expanded primate CTL population, the CTL population: (i) depleted of FoxP3+ T lymphocytes prior to antigen stimulation; (ii) antigen-stimulated in vitro in the presence of interleukin-21; or (iii) both depleted of FoxP3+ T lymphocytes prior to antigen stimulation and then antigen-stimulated in vitro in the presence of interleukin-21. Methods of preparing such compositions, and compositions useful for carrying out the adoptive immunotherapy, are also described.
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