Functionalized porous silicon nanoparticles and use thereof in photodynamic therapy

摘要

Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.