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Alpha- and chi-diketone reactants for charge transfer reactions in mass spectrometers

机译:质谱仪中用于电荷转移反应的α-和Chi-二酮反应物

摘要

The invention relates to the use of substances for the production of anions suitable for charge transfer reactions in mass spectrometers, particularly for the fragmentation of multiply positively charged biopolymer ions by electron transfer or for charge reduction by proton transfer. Diketones, particularly α-diketones, are proposed as a newly found class of substances which can be used both for the production of radical anions for electron transfer dissociations (ETD) with a high yield of fragment ions and also for the production of non-radical anions for the charge reduction of multiply charged analyte ions by proton transfer reactions (PTR). These substances have favorable properties in terms of their handling and the associated analytical methods: they are largely nontoxic, cover a favorable range of molecular masses, and their volatility means that they can be stored in unheated containers outside of the vacuum system, which facilitates the refilling of the containers.
机译:本发明涉及用于制备适合于质谱仪中的电荷转移反应的阴离子的物质的用途,特别是用于通过电子转移使多个带正电荷的生物聚合物离子破碎或通过质子转移使电荷还原的物质。提出了二酮,特别是α-二酮,作为新发现的一类物质,既可以用于产生自由基阴离子,从而以高产率的碎片离子产生电子转移离解(ETD),也可以用于产生非自由基通过质子转移反应(PTR)减少多电荷分析物离子的电荷的阴离子。这些物质在其处理和相关的分析方法方面均具有良好的性能:它们在很大程度上无毒,覆盖分子质量的良好范围,并且其挥发性意味着可以将它们存储在真空系统之外的未加热容器中,这有助于重新装满容器。

著录项

  • 公开/公告号US9557297B2

    专利类型

  • 公开/公告日2017-01-31

    原文格式PDF

  • 申请/专利权人 BRUKER DALTONIK GMBH;

    申请/专利号US201213667018

  • 发明设计人 RALF HARTMER;

    申请日2012-11-02

  • 分类号G01N24/00;G01N27/62;H01J49/00;C07C49/12;C07C49/203;C07C49/403;C07C49/437;

  • 国家 US

  • 入库时间 2022-08-21 13:41:56

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