Molecules from the Soviet Union to Antarctica include a movement linking the TNF family

摘要

The application relates to Antigen binding molecules containing a trimer of TNF Family ligand comprising (a) at least one Rest capable of binding specifically to a target cell Antigen and (b) a First and a Second polypeptide that are linked together by u No disulfide bond.Characterized by the first polypeptide comprises two ectodomains of a member of the TNF Family ligands or Fragments thereof which are interconnected by a Peptide Linker and the second polypeptide comprises an ectodomain of the Member of the Family Lia ligands TNF or a fragment thereof.