Compositions of RNAi against factor XII (Hageman factor) (F12), calicreu00cdna B, PLASMu00c1TICA (factor 1 (Fletcher), and quininu00d3geno Klkb1) 1 (kng1) and Methods of Use thereof

摘要

This is related to RNAi agents, for example, agents of RNAi against Double stranded b gene, plasma kallikrein, factor (Fletcher) 1 (Klkb1), The Gene of factor XII (Hageman factor (F12), or quininu00f3geno Gene 1 (kng1), and Methods of use these Agents for RNAi Inhibit the expression of a Gene, a Gene Klkb1, F12, and / or a Gene kng1,And Methods for treating subjects with Hereditary angioedema (HAE) and / or a disorder associated with Channel Activation by contact. Cell, vector, Pharmaceutical composition.