Method for preparing an antibiotic of the penicillin ticarcillin disodium prolonged action of broad spectrum

摘要

Method for preparing an antibiotic of the penicillin ticarlina disodium prolonged action of broad spectrum.The present invention provides a method to prepare a ticarcina disodium with a moderate reaction condition, less for lateral, few steps and strong controllability.That includes the steps of: (1) reacting 3 - tiofenomalonico acid with N - hydroxyl succinimide in an organic solvent under a catalyst of DCC and DMAP to obtain an intermediate which is isolated and purifBy the chromatographic column; (2) dissolving the intermediate in dichloromethane and then add 6 - APA and an alkali to obtain a ticarcillin through reaction; (3) to respond to ticarcillin with an agentAnd the formation of salt to obtain a ticarcillin disodium.