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prolonged release formulations for protein delivery to the eye and methods of preparing them
prolonged release formulations for protein delivery to the eye and methods of preparing them
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机译:蛋白质释放到眼中的缓释制剂及其制备方法
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摘要
The present invention provides for injectable pharmaceutical sustained release formulations for delivery of active agents, particularly therapeutic proteins, to the eye. The formulations are biocompatible, biodegradable sustained release formulations comprising low-solubility liquid excipients and relatively small amounts (less than about 10%) of biocompatible, biodegradable polymer such as PLA or PLGA polymers. A unit dose of 5 μL to 100 μL of the formulation provides for sustained release of the agent for at least 14 days.
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