compound, method for inhibiting pak1 activity in a cell and patient, method for treating or improving the severity of cancer or a hyperproliferative disorder in a patient, use of the compound and composition

摘要

Compounds having the formula I wherein A, Z, R1a, R1b, R2, R3, R4, R5, R6, R7, R9, R10, Ra, Rb and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.