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methods for probing multiple targets in a biological sample and for analyzing the high throughput multiplexing biological sample, and at least two images series
methods for probing multiple targets in a biological sample and for analyzing the high throughput multiplexing biological sample, and at least two images series
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机译:探测生物样品中多个目标并分析高通量多路复用生物样品的方法,以及至少两个图像系列
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摘要
Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with an electron transfer reagent and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The process of binding, observing and bleaching may be iteratively repeated.
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