anti-gcc antibody molecules and use of them for susceptibility testing for gcc-targeted therapy

摘要

Summary anti-gcc antibody molecules and their use for gcc-directed therapy susceptibility testing The present invention relates to antibodies and antigen-binding fragments of gcc-binding antibodies. The invention also provides diagnostic methods for identifying patients who should receive gcc-targeted therapy using the anti-gcc antibodies provided herein. anti-gcc antibody molecules are useful as naked antibody molecules and as immunoconjugate components. therefore, in another aspect, the invention features immunoconjugates consisting of an anti-gcc antibody molecule described herein and a therapeutic agent or label. The invention also provides methods for using the anti-gcc and immunoconjugate antibody molecules described herein, for example, for detecting gcc and gcc-expressing cells or tissues. Such methods are useful in particular for the diagnosis, prognosis, imaging, or staging of a gcc-mediated disease. Accordingly, in some aspects, the invention provides methods of identifying an individual for treatment with a target gcc therapy, for example, anti-gcc antibody therapy, for example, an immunoconjugate composed of a conjugated anti-gcc antibody. with a therapeutic agent.