topical liquid agent for the treatment of dermatophytosis

摘要

Patent Summary: "Topical liquid agent for the treatment of dermatophytosis". According to the present invention, a topical liquid agent having antifungal activity against dermatophytes, and additionally high nail permeability, may be provided. The topical nail and / or skin topical agent for the prevention or treatment of dermatophytosis comprises a film-forming agent and a compound represented by the formula: wherein R1 represents a hydrogen atom, C1-6 alkyl, or trifluoromethyl, R2 represents an atom hydrogen, C1-6 alkyl, halogen, -coo (C1-6 alkyl), or (ch2) 1-3coor where r represents a hydrogen atom or c1-6 alkyl, r3 represents a hydrogen atom, c1-6 alkyl , amino, trifluoromethyl, or where r represents a hydrogen atom or c 1-6 alkyl, r 4 represents a hydroxyl group, r 5 represents a hydrogen atom, c 1-6 alkyl, a hydroxyl group, or halogen, r 6 represents a hydrogen, C1-6 alkyl, trifluoromethyl, halogen, amino, -nrarb, nitro, hydroxy-C1-6 alkyl, -conrarb, -coo (C1-6 alkyl), -cooh, - (ch2) 1-3coor, ora where r represents a hydrogen atom or c 1-6 alkyl, ra and rb each represent a hydrogen atom, c 1-6 alkyl a, or c 1-6 acyl, r 7 represents a hydrogen atom, c 1-6 alkyl, -or where r represents a hydrogen atom or c 1-6 alkyl, or halogen, r 8 represents a hydrogen atom, c 1-6 alkyl, a hydroxyl, amino, or nitro group or a salt thereof.