partially cross-linked esterified cellulose ether, composition, solid dispersion, process for producing solid dispersion, dosage form and capsule shell

摘要

abstract "partially cross-linked esterified cellulose ether, composition, solid dispersion, process for producing solid dispersion, dosage form and capsule shell" a partially cross-linked esterified cellulose ether having (a) groups of the formula -c (o) -r -coa or a combination of monovalent acyl groups and groups of the formula -c (o) -r-cooa, where r is a bivalent aromatic or aliphatic hydrocarbon group and a is hydrogen or a cation, and (b) have a distribution of molecular weight such that [wf ( 100k) -wf ( 100k) xl] / wf ( 100k) xl is at least 0.20, where wf ( 100k) is the total weight fraction of esterified cellulose ether that exceeds 100,000 g / mol, and wf ( 100k) xl is the weight fraction exceeding 100,000 g / mol of methylated esterified cellulose ether, useful as an enteric polymer for pharmaceutical dosage forms.