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new compound with effects of thrombolysis, free radical elimination and thrombus targeting as well as method of preparation and use

机译:具有溶栓作用,自由基消除和血栓靶向作用的新型化合物及其制备和使用方法

摘要

Abstract "New compound with thrombolysis, free radical elimination and thrombus targeting effects as well as method of preparation and use thereof" The present invention discloses a new compound with thrombolysis, free radical elimination and thrombus targeting effects as well as a method of preparation and use thereof. The compound is a ternary conjugate formed by conjugation to a thrombolytic peptide, a free radical scavenger, and a thrombus / antithrombotic targeting peptide joined via a linker arm. The present invention also discloses a pharmaceutical composition containing the compounds, wherein the compounds form a nanospheric structure.
机译:摘要“具有溶栓,消除自由基和血栓靶向作用的新型化合物及其制备和使用方法”本发明公开了一种具有溶栓,消除自由基和血栓靶向作用的新型化合物及其制备和使用方法。其。该化合物是通过与通过连接臂连接的血栓溶解肽,自由基清除剂和血栓/抗血栓靶向肽缀合形成的三元缀合物。本发明还公开了包含所述化合物的药物组合物,其中所述化合物形成纳米球结构。

著录项

  • 公开/公告号BR112015004854A2

    专利类型

  • 公开/公告日2017-07-04

    原文格式PDF

  • 申请/专利权人 SHANGHAI LUMOSA THERAPEUTICS CO. LTD.;

    申请/专利号BR20151104854

  • 发明设计人 MING ZHAO;SHIQI PENG;XUEYUN JIANG;

    申请日2013-03-15

  • 分类号A61K38/08;A61P7/02;A61P9/10;A61P39/06;C07K1/06;C07K7/06;

  • 国家 BR

  • 入库时间 2022-08-21 13:40:17

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