testosterone derivatives with a carboxyalkyl substitution at position 3 and their use to produce labeled steroids to determine testosterone concentration in a biological sample

摘要

Patent Summary: "Testosterone derivatives with a 3-carboxyalkyl substitution and use thereof for the production of labeled steroids to determine testosterone concentration in a biological sample". The present invention relates to testosterone derivatives of formula (i): wherein n is an integer between 1 and 10 and y represents an activated or ready to be activated group allowing the formation of an amide bond with an amine. It also refers to conjugates consisting of these testosterone derivatives and a marker, as well as their use to determine the concentration of testosterone in a biological sample. Finally, it refers to methods for preparing testosterone derivatives.