SYNTHESIS OF ADENOSINE DERIVATIVES WITH CARBOXYALKYL SIDE CHAIN AT 2',3'OR 5'POSITION

摘要

Some nucleoside carhoxylic acid derivatives,such as(±)ethyl ester of griseolic acid(4)and 9-(2’-deoxy-2’-(benzyloxycarbonyl)-methylene-β-D-rihohept-2’-enofuranosyluranate)adenine(11),were synthesized.The formation of lactone of 5’-deoxy-adenosineacetic acid(AAA,3)wasinvestigated by using different reagents for lactonization from AAA,but all of the efforts failed,and sone unexpected compounds were obtained.