bisphenyl substituted butanoic acid derivatives as nep inhibitors with improved in vivo efficacy

摘要

Patent Summary: "Bisphenyl-substituted butanoic acid derivatives as nep inhibitors with improved in vivo efficacy". The present invention relates to a compound of formula (I); or a pharmaceutically acceptable salt thereof, wherein x is defined in this application. The invention also relates to a method for producing the compounds of the invention and their therapeutic uses. The present invention further provides the pharmaceutical composition of the compounds of the invention and a combination of pharmacologically active agents and a compound of the invention.