compound of formula, prodrug of a compound, kit, methods for regulating a trajectory, for regulating any one or more enzymes, for reducing metabolites, for altering tryptophan levels, for treating immune suppression, for reducing or eliminating an immune-mediated disorder , to inhibit enzyme activation, to treat a disease, to inhibit an autoimmune antibody production, to prepare a compound, and to diagnose and treat a disease and compound obtainable by a method.

摘要

summary “compound of formula, prodrug of a compound, kit, methods to regulate a trajectory, to regulate any one or more enzymes, to reduce metabolites, to alter tryptophan levels, to treat immune suppression, to reduce or eliminate a immune-mediated disorder, to inhibit enzyme activation, to treat a disease, to inhibit autoimmune antibody production, to prepare a compound and to diagnose and treat a disease and compound obtainable by a method ”the present application provides innovative indoleamine inhibitors 2 , 3-dioxigenase-1 and / or indoleamine 2,3-dioxigenase-2 and / or tryptophan 2,3-dioxigenase, metabolites thereof and pharmaceutically acceptable salts or prodrugs thereof. Methods for preparing such compounds are also provided. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in the treatment of diseases resulting from quinurenine pathway dysregulation. The compounds of formula (I) act by inhibiting the activity or enzymatic expression of indoleamine 2,3-dioxigenase-1 and / or indoleamine 2,3-dioxigenase-2 and / or tryptophan 2,3-dioxigenase.