Antibody - drug conjugate anti trop2, antitumor and / or anticancer drug, pharmaceutical composition and use of the same.

摘要

It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L 1 -L 2 -L P -NH-(CH 2 )n 1 -L a -(CH 2 )n 2 -C(=O)- wherein the anti-TROP2 antibody is connected to the terminal of L 1 , and the antitumor compound is connected to the carbonyl group of the -(CH 2 )n 2 -C(=O)- moiety with the nitrogen atom of the amino group at position 1 as a connecting position.