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antibody-based transthyretin amyloidosis (ttr) therapy and its human-derived antibodies.
antibody-based transthyretin amyloidosis (ttr) therapy and its human-derived antibodies.
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机译:基于抗体的转甲状腺素蛋白淀粉样变性(ttr)治疗及其人类衍生抗体。
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摘要
Provided are novel human-derived antibodies specific for transthyretin (TTR), preferably capable of binding misfolded, misassembled, and/or aggregated TTR species, as well as methods related thereto. In addition, methods of diagnosing and/or monitoring diseases and treatments thereof which are associated with TTR amyloidosis are provided. Assays and kits related to antibodies specific for TTR or TTR deposits and aggregates are also disclosed. The novel anti-TTR antibodies can be used in pharmaceutical and diagnostic compositions for TTR targeted immunotherapy and diagnostics.
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