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pharmaceutically acceptable compound and / or salts thereof, process for compound synthesis, and aerosol formulation, and use of at least one phenylphosphate mutual prodrug
pharmaceutically acceptable compound and / or salts thereof, process for compound synthesis, and aerosol formulation, and use of at least one phenylphosphate mutual prodrug
A mutual prodrug of a corticosteroid and a substituted phenylphosphate (-agonist derivative) for formulation for delivery by aerosolization to inhibit pulmonary inflammation and bronchoconstriction is described. The mutual prodrug is preferably formulated in a small volume solution (10-500 L) dissolved in a quarter normal saline having pH between 5.0 and 7.0 for the treatment of respiratory tract inflammation and bronchoconstriction by an aerosol having mass median average diameter predominantly between 1 to 5, produced by nebulization or by dry powder inhaler.
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