peptide, truncated amino- and / or carboxyl segment of the peptide, nucleotide sequence, expression vector, host cell, fusion protein, pharmaceutically pure preparation, composition, method for stabilizing atherosclerotic plaque and reducing the occurrence of plaque rupture events , method of reducing inflammation and lipid deposition and increasing collagen and elastin deposition within the intimate lesion, method of tgf-b1 activation and / or deactivation of mmm-9 and method for modulating tgf-b1 activity and / or mmm-9

摘要

Treatments employing the matricellular protein thrombospondin-1 (TSP-I) and related compositions are disclosed for stabilizing atherosclerotic plaque and decreasing occurrence of plaque rupture events leading to, for example, myocardial infarction, stroke, and acute limb ischemia. Various peptides, including certain synthetic peptides, related to TSP-I are also disclosed. Such peptides have utility in stabilizing plaque in various contexts, including the disease states mentioned above. Some of these peptides include one or more sequences related to active sites of TSP-I for regulating, e.g., TGF-ss1 and MMP-9 activity. Experimental data show that a representative peptide provides a beneficial effect with systemic injection of the peptide.