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ANTIBODIES WITH INCREASED ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY ACTIVITY, PROCEDURES FOR THE PRODUCTION OF THESE AND USE THEREOF
ANTIBODIES WITH INCREASED ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY ACTIVITY, PROCEDURES FOR THE PRODUCTION OF THESE AND USE THEREOF
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机译:依赖于抗体的细胞毒性作用的抗体及其生产和使用方法
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摘要
The invention relates, in part, to antibodies with increased ADCC activity. Methods of producing such antibodies are also provided. The antibodies of the invention are produced in mammary epithelial cells, such as those in a non-human transgenic animal engineered to express and secrete the antibody in its milk. The antibodies or compositions comprising the antibodies can be used to treat disease in which ADCC activity provides a benefit. In one embodiment, therefore, the antibodies or compositions comprising the antibodies can be used to treat cancer, lymphoproliferative disease or autoimmune disease.
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