PHARMACEUTICAL DOSAGE FORM COMPRISING NIFEDIPINE OR NISOLDIPINE AND AN ANGIOTENSIN-II ANTAGONIST AND/OR A DIURETIC

摘要

The invention relates to a pharmaceutical dosage form comprising a biologically active ingredient combination of nifedipine and at least one angiotensin-II antagonist selected from candesartan and telmisartan and/or at least one diuretic selected from hydrochlorothiazide and chlorthalidone, comprising a core and a mantle coating around the core, wherein at least 85% of the nifedipine (based on the declared total amount of each biologically active ingredient) are released over a period of 24 hours, from 5 to 17% of the nifedipine are released over a period of 4 hours and from 43 to 80% of the nifedipine are released over a period of 12 hours, and at least 60% of the angiotensin-II antagonist and/or the diuretic (based on the declared total amount of each biologically active ingredient) are released over a period of 30 minutes according to the USP release method using apparatus 2 (paddle) at 75 rpm in 900 ml of a suitable medium, and also to a method for production thereof.