HYBRID PROTEIN, DNA, GENETIC CONSTRUCTION, PRODUCER, VACCINE BASED ON HYBRID PROTEIN FOR PREVENTION AND TREATMENT OF TUBERCULOSIS (OPTIONS)

摘要

The group of inventions relates to molecular biology, biotechnology, medicine and can be used to implement the prevention and treatment of tuberculosis. Hybrid proteins, including immunogenic fragments of proteins Ag85B, Tb10.4 M. tuberculosis, FliC S. Typhimurium, connected by flexible bridges, encoding polynucleotides, genetic constructs for the expression of polynucleotides, producers and variants of the vaccine for the prevention and treatment of tuberculosis based on the described hybrid protein, are proposed. The consumer of a developed vaccine is a human or an animal. The proposed vaccine has an efficacy greater than that of BCG. Inventions claimed to obtain this vaccine ensure its safety and simplicity in production and use.