PEPTIDES THAT PERFORM THE ROLE OF OXYTOCINE AGONISTS

摘要

The invention relates to compounds of the formula where R is hydrogen, lower alkyl or cycloalkyl; R is hydrogen or R and R may form together with the N atom and C atom to which they are attached a pyrrolidine ring, optionally substituted with one or two F atoms or a hydroxyl group, or may form an azetidine or piperazine ring; R is hydrogen, lower alkyl, lower alkyl substituted by a hydroxyl group, - (CH) C (O) NH, benzyl, phenyl, —CH-five-membered aromatic heterocyclic group, CH-indolyl, —CH-cycloalkyl, cycloalkyl or - (CH) -S-lower alkyl; Is hydrogen or lower alkyl; or X is —C (O) —CHR — CHR — C (O) —NH — CH—, R / R is hydrogen, or one of R or R is an amino group; o means 0 or 1; or to their pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and / or its optical isomers. The present compounds have been found to be oxytocin receptor agonists for the treatment of autism, stress, including post-traumatic stress disorder, anxiety, including anxiety disorders and depression, schizophrenia, mental disorders and memory loss, alcohol withdrawal, drug dependence, and also for the treatment of Pradora syndrome Willy.