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Humanized fcγr mice and methods of screening an agent comprising an fc region of a human antibody
Humanized fcγr mice and methods of screening an agent comprising an fc region of a human antibody
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机译:人源化fcγr小鼠和筛选包含人抗体fc区域的试剂的方法
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摘要
Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity Fc³R locus, and wherein the mouse is capable of expressing a functional FcR³-chain. Genetically modified mice are described, including mice that express low affinity human Fc³R genes from the endogenous Fc³R locus, and wherein the mice comprise a functional FcR³-chain. Genetically modified mice that express up to five low affinity human Fc³R genes on accessory cells of the host immune system are provided.
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