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Novel tilapia virus and uses thereof

机译:新型罗非鱼病毒及其用途

摘要

The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.
机译:本发明涉及分离的罗非鱼湖病毒或TiLV,以及分离的核酸序列和多肽。本发明还涉及探针和引物,以及针对来自TiLV的抗原的抗体,以及这些试剂在检测动物中是否存在TiLV的用途。本发明还涉及靶向TiLV的核酸序列的iRNA。本发明还涉及用于在动物中诱导针对TiLV的免疫应答的免疫原性组合物,包括抗体和疫苗。本发明还涉及用于开发预防剂和治疗剂的包含TiLV和分离的核酸序列及其多肽的基因构建体和细胞。

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