SUSTAINED-RELEASE NANO-PARTICLE PHARMACEUTICAL FORMULATION UTILIZING AZADIRACHTA INDICA FRUIT MUCILAGE AND CHITOSAN AS MATRIX FORMERS AND METHOD OF PRODUCTION THEREOF

摘要

Applicant: SRI RAMACHANDRA UNVIERSITY Title: SUSTAINED-RELEASE NANO-PARTICLE PHARMACEUTICAL FORMULATION UTILIZING AZADIRACHTA INDICA FRUIT MUCILAGE AND CHITOSAN AS MATRIX FORMERS AND METHOD OF PRODUCTION THEREOF ABSTRACT The present invention relates to a novel biocompatible sustained-release nano-particle pharmaceutical formulation and method of preparation thereof. The formulation comprises of at least one therapeutic drug entrapped in a bio degradable antimicrobial activity exhibiting polymeric carrier to form a polymer nano-carrier system. The formulation is characterized in the bio degradable polymer comprising of chitosan as cationic polymer and polysaccharides extracted from Azadirachta indica fruit mucilage as an anionic polymer in which the therapeutic drug is complexed with the polymer thereby it retains the biological activity of the drug. The present invention also discloses the process of production of novel biocompatible sustained-release nano-particle pharmaceutical formulation by the modified coacervation method via the interactions between OH- groups of Azadirachta indica with COO- group of chitosan using different concentrations of polymeric solutions as carriers to prolong the drug release and thus bioavailability and therapeutic efficacy of the drug can be enhanced.