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COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING CHRONIC LUNG ALLOGRAFT DYSFUNCTION AND IDIOPATHIC PULMONARY FIBROSIS
COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING CHRONIC LUNG ALLOGRAFT DYSFUNCTION AND IDIOPATHIC PULMONARY FIBROSIS
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机译:预防或治疗慢性肺异种移植物功能异常和特发性肺纤维化的组合物和方法
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摘要
The described invention provides compositions and methods for reducing lung allograft dysfunction after lung transplant and for treating a severe pulmonary fibrosis characterized by aberrant fibroblast proliferation and extracellular matrix deposition in a tissue of a subject. The methods comprise administering to a subject in need thereof a composition comprising an antibody component comprising a therapeutic amount of an anti CD44 antibody; and an MK2 inhibitor component comprising a therapeutic amount of an MK2 inhibitor (MK2i) polypeptide of amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or at least one peptide functionally equivalent to the therapeutic domain thereof selected from a polypeptide of amino acid sequence KALARQLAVA (SEQ ID NO: 8) a polypeptide of amino acid sequence KALARQLGVA (SEQ ID NO: 9) and a polypeptide of aminoacid sequence KALARQLGVAA (SEQ ID NO: 1) or a functional equivalent thereof and a pharmaceutically acceptable carrier.
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机译:所描述的本发明提供了组合物和方法,其用于减少肺移植后的肺同种异体移植功能障碍和用于治疗以受试者的组织中异常的成纤维细胞增殖和细胞外基质沉积为特征的严重肺纤维化。所述方法包括向有需要的受试者施用包含抗体成分的组合物,所述抗体成分包含治疗量的抗CD44抗体;和以及MK2抑制剂成分,其包含治疗量的选自氨基酸序列KAARAQLAVA的氨基酸序列YARAAARQARAKALARQLGVAA(SEQ ID NO:1)的MK2抑制剂(MK2i)多肽或至少一种功能等同于其治疗结构域的肽(SEQ ID NO:8)氨基酸序列KALARQLGVA的多肽(SEQ ID NO:9)和氨基酸序列KALARQLGVAA的多肽(SEQ ID NO:1)或其功能等价物和药学上可接受的载体。
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