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OXYNTOMODULIN ANALOGUES AND THEIR EFFECTS ON FEEDING BEHAVIOUR
OXYNTOMODULIN ANALOGUES AND THEIR EFFECTS ON FEEDING BEHAVIOUR
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机译:缩醛莫杜林类似物及其对进食行为的影响
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摘要
Compounds of the invention are novel peptide analogues of oxyntomodulin (oxm) in which one or more amino acids of the oxm sequence have been changed. Changing amino acids 15-24 of oxm to either amino acids 968 - 977 of the a-latrotoxin peptide (and variations thereof) or amino acids 15 -24 of exendin-4 (and variations thereof), or combinations of sequences from these sources, and/or changing amino acids 27 - 33 of oxm to amino acids 27 - 33 of exendin-4, and/or the addition of amino acids to the C-terminus of the peptide, results in a series of analogues of oxm that demonstrate the oxm like activity of reducing food intake, and with certain embodiments a greater ability to decrease food intake.
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