gamma - diketones as activators of the wnt signalling pathway. - catenin

摘要

The present invention relates to? -Diketones or analogs thereof, which activate wnt / ß-catenin signaling and therefore treat or prevent diseases associated with signal transduction, such as osteoporosis and osteoarthropathy;Imperfect osteogenesis, bone defect, fracture, periodontal disease, ear sponge disease, wound healing, craniofacial defect, tumor osteopathy, brain injury and spinal injury Brain / neural atrophy disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, cerebrovascular disease, ischemic brain disease, epilepsy, Alzheimer's disease, depression, bipolar disease, schizophrenia;Ear diseases, such as loss of ciliary cells in the cochlea;Eye diseases, such as age-related macular degeneration, diabetic macular edema or retinitis pigmentosa, and diseases related to stem cell differentiation and growth, such as hair damage, Hematopoiesis and tissue regeneration