Chloro-{N-(3,4-dimethylphenyl)-2-1-(2-hydroxyphenyl)ethylidene-hydrazinecarbothioamido(1-)}nickel, exhibiting antimicrobial activity against Klebsiella pneumoniae and Pseudomonas aeruginosa bacterial species

摘要

The invention relates to chemistry and medicine, namely to a new biologically active coordinative nickel compound from the class of thiosemicarbazonates of transition metals and can find application in medicine and veterinary medicine as antimicrobial preparations or ingredient in the creation of selective microbiological nutrient media.Summary of the invention consists in obtaining a coordinative compound with high antibacterial activity chloro-{N-(3,4-dimethylphenyl)-2-[1-(2-hydroxyphenyl)ethylidene]-hydrazinecarbothioamido(1-)}nickel of Formula:This compound exhibits bacteriostatic and bactericidal activity against gram-negative Klebsiella pneumoniae and Pseudomonas aeruginosa bacterial species in the concentration range of 0.7…3.0 µg/mL.