USE OF THE ACETIC ACID COMPOUND 2-1-(1R)-1-3-2-(7-CHLOROQUIN OLIN-2-YL) ETENYL PHENYL-3-2-(2-HYDROXYPROPAN-2-) PHENYL PROPYL SULFANYLMETHYL CYCLOPROPYL AS ALOSTERIC INHIBITOR OF THE DENGUE VIRUS NS2B/NS3 PROTEASE.

摘要

The present disclosure is related to a new use of the acetic acid compound 2-[1-[[(1R)-1-[3-[2-(7-chloroquinolin-2-yl) ethenyl] phenyl]-3-[2-(2-hydroxypropan-2-yl) phenyl] propyl] sulfanylmethyl] cyclopropyl] (Montelukast) as an allosteric inhibitor of the the dengue virus protease NS2B / NS3, with the aim of eradicating the reproduction of the dengue virus in infected people by adhesion of the compound to the activation site of the complex forming the NS2B and NS3 proteins, proteases precursors of the dengue viral polyprotein. The compound is effective when the virus has infected human cells, specifically monocytes, hepatocytes, neurons, kidney cells. The compound binds to a conserved site behind the active site, causing the NS2B and NS3 protein complex to lose the protease function. The acetic acid compound 2-[1-[[(1R)-1-[3-[2-(7-chloroquinolin-2-yl) ethenyl] phenyl]-3-[2-(2-hydroxypropan-2-yl) phenyl] propyl] sulfanylmethyl] cyclopropyl] (Montelukast) is characterized by having a m inimal inhibitory dose of 160 ug/ml and a maximum inhibitory dose of 10 mg/ml in humans.