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TREATMENT OF HEREDITARY ANGIOEDEMA WITH C1 INHIBITOR.
TREATMENT OF HEREDITARY ANGIOEDEMA WITH C1 INHIBITOR.
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机译:用C1抑制剂治疗遗传性血管病。
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摘要
A method for treating acute attacks of hereditary angioedema (HAE) whereby a first dose and a second dose of a recombinant C1 esterase inhibitor is administered intravenously to the patient, each dose at 50 IU/kg body weight of the patient and wherein the first and second doses are administered within a 24 hour period. The recombinant C1 esterase inhibitor has an amino acid sequence identical to the amino acid sequence of human plasma-derived C1 esterase inhibitor and a modified carbohydrate structure as compared to the human plasma-derived C1 esterase inhibitor. Relief of attack symptoms as well as reduction of relapse and/or new attack symptoms are achieved by use of the method.
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机译:一种用于治疗遗传性血管性水肿(HAE)急性发作的方法,该方法是向患者静脉内注射第一剂和第二剂重组C1酯酶抑制剂,每种剂量为患者50 IU / kg体重,其中第一剂和第二剂在24小时内给予第二剂。与人血浆来源的C1酯酶抑制剂相比,重组C1酯酶抑制剂具有与人血浆来源的C1酯酶抑制剂的氨基酸序列相同的氨基酸序列,并且修饰的碳水化合物结构。通过使用该方法,可以减轻发作症状并减少复发和/或新的发作症状。
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