PEPTIDE-BASED IN VIVO SIRNA DELIVERY SYSTEM.

摘要

The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepaiocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted me!ittm dehvery peptides. Dehvery peptides provide membrane penetration faction for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.