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Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories
Stable povidone-iodine compositions with steroids or non-steroidal anti-inflammatories
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机译:具有类固醇或非类固醇抗炎药的稳定的聚维酮碘组合物
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摘要
Disclosed are stable ophthalmic composition, comprising: 0.3 to 1% (w/w) polyvinylpyrrolidinone-iodine complex; 0.05 to 2% (w/w) non-steroidal anti-inflammatory drug (NSAID) bromfenac, or 0.05 to 2% (w/w) steroid selected from the group consisting of prednisolone acetate, loteprednol etabonate, difluprednate, hydrocortisone acetate, and combinations thereof; 0.005% to 0.02% (w/w) EDTA; 0.01 to 0.5% (w/w) sodium chloride; 0.02 to 0.1% (w/w) tyloxapol as a co-solvent/surfactant; 0.5% to 2% (w/w) sodium sulfate; and 0.1 to 0.5% (w/w) hydroxyethylcellulose as a viscosity increasing agent. These ophthalmic compositions are suitable for the treatment and/or prophylaxis of an eye disorder selected from the group consisting of a microorganism infection of at least one tissue of the eye, conjunctivitis, corneal abrasion, ulcerative infectious keratitis, epithelial keratitis, stromal keratitis and herpesvirus-related keratitis.
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