Pyrazine derivatives as modulators of epithelial sodium channel (ENAC)

摘要

Pyrazine derivatives relates to compounds of formula (i), wherein R1 is H or c1-c4 alkyl, M is 1 or 2; is phenyl or heterociclilo; X is - C (= o) -, - C (= o) - NR4.Among others, N is 2 or 3; R2 is H, or C1 C8 alkyl alkyl; R3 is C5 C6 Oh where is substituted alkyl; R4 is H or c1-c4 alkyl.Preferred compounds are: 3.5 - diamino - 6 - Chloro - (R) - N - (2 - (2-methylbenzyl) - 3 - (((1 - (3 - ((2S, 3R, 4R) - - tetrahidroxipentil 2,3,4,5) amino) propanoil) piperidin-4-yl yl) methyl) Amine) propyl) pyrazine-2-carboxamide; 35 - diamino - 6 - Chloro - (N - (R) - 3 - ((4 - ((2 - (Hexyl ((2S, 3R, 4R) - - tetrahidroxipentil 2,3,4,5) amino) ethyl) Carbamoyl) benzyl) amino) - 2 - (2-methylbenzyl) propyl) pyrazine - 2 - carboxamide; among others.It also relates to a combination that includes.These compounds are modulators of epithelial sodium channel (ENAC) being useful in the treatment of diseases such as cystic fibrosis, Asthma, COPD, among others