3,5-disubstituted and 3,4,5-trisubstituted isoxazoles and their preparation

摘要

the subject invention is 3.5 - dipodstawione and three, four, five - tripodstawione izoksazole about general patterns 1a, 1b, 1c and 1d, where: ar - means a one - or wielopieru015bcieniowu0105 arylowu0105 group, in particular, 2,4 - dichlorofenyl, 2,4 - dibromofenyl, 2,4 - difluorofenyl, 2,6 - dichlorofenyl, 2,4 - dimetylofenyl, 2,4 - dimetoksyfenyl, 3,4 - metylenodioksyfenyl, 2,6 - dimetylofenyl, 2,6 - difluorofenyl, 2.4,6 - trimetylofenyl, 2,4,6 - trimetoksyfenyl, 9 - antracenyl; q - means or a sterycznie, or niepodstawionu0105, one - or wielopieru015bcieniowu0105 arylowu0105 group, in particular, 2,2 '- bitiofen - 5 - yl, 9 - antracenyl, 1 - naftyl; and - means in the form of difunkcyjnej adapter group arylowej lu (b heteroarylowej, in particular, 1,2 - phenylene phenylene, 1,3 -, 1,4 - phenylene, anthracene - 9,10 - diyl.the invention also includes a method for receiving in the reaction cykloaddycji dipolarnej oxides of aromatic or aromatic nitryli ditlenku00f3w dinitryli to mono - and symmetrically dipodstawionych alkynes in solvents such as short chain alcohols, ethyl ether, chlorowc oalkany saturated acetone or methylene chloride or any mixture of them favourably.these reactions are less reactive substrates on and developed sterycznie dipolarofile. reactions carried out under high pressure from 0.5 to 2.0 gpa, at a temperature of from 10 to 110u00b0c in time from 1 to 48 h, in an inert gas atmosphere, preferably argon.compounds obtained this way may be used inter alia as pharmaceuticals, substrates for further syntez or precursors of nanomaterials for organic electronics.