Method for synthesis and purification of nucleoside and/or nucleotide, the modified nucleoside and/or nucleotide, DNA particle and the oligonucleotides library containing the modified nucleoside and/or nucleotide and the application of the oligonucleotides library

摘要

The method of synthesis and purification of mono-nucleoside and/or mono-nucleotide shall be reported,di- or tri-phosphate, consisting of the reaction of Huisgen alkaline-oxide cycling compound with a compound selected from a group of compounds with general patterns from 2 to 5. The notification shall also cover modified nucleoside and/or generic nucleotide 1, DNA molecule and oligonucleotide library containing one or more modified nucleotides and the use of the oligonucleotide library for the selection of pharmacometers.