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CELL LINE OF LYMPHOCYTES COMPRISING GAMMA-DELTA T CELLS, COMPOSITION AND PRODUCTION METHOD THEREOF
CELL LINE OF LYMPHOCYTES COMPRISING GAMMA-DELTA T CELLS, COMPOSITION AND PRODUCTION METHOD THEREOF
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机译:包含γ-δT细胞的淋巴细胞的细胞系,组成和生产方法
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摘要
The present invention shows that human Vδ1+ NCR+ T cells can be differentiated and expanded from total γδ peripheral blood lymphocytes (PBLs), upon regular in vitro or ex vivo stimulation with γδTCR agonists and γc-family cytokines. This subset surprisingly expresses NKp30, NKp44 and NKp46, and high levels of Granzyme B that associate with highly enhanced cytotoxicity against lymphoid leukemias.
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