substituted purine derivatives, 2.6 - and their use in the treatment of disorders proliferatifs.

摘要

The invention relates to formula Ltbr (I) or pharmaceutically acceptable salt thereof.In the formula, q.g. nuclear a,le noyau BR 26lt sup 26gt 1 26lt 2Fsup 26gt R 26lt sup 26gt 2 26lt 2Fsup 26gt R 26lt sup 26gt 3 26lt 2Fsup 26gt R 26lt sup 26gt 4 26lt 2Fsup 26gt R 26lt sup 26gt 5 26lt 2Fsup 26gt R 26lt sup 26gt 6 26lt 2Fsup 26gt R sup 24 /sup and m meet the definitions in this brief. The novel purine derivatives are useful in the treatment of abnormal cell growth,Such as cancerIn mammals Additional embodiments of the pharmaceutical composition containing the compound and methods for treating mammalian abnormal cell growth using the compound and the composition