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Binding associated placental growth factor, in particular antibodies directed against placental growth factor, their production and use
Binding associated placental growth factor, in particular antibodies directed against placental growth factor, their production and use
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机译:结合相关的胎盘生长因子,特别是针对胎盘生长因子的抗体,其产生和用途
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摘要
Immunologically active peptide (I), comprising sequence information of a primary placental growth factor isoform (PIGF), is new. Independent claims are included for: (1) a specific binding partner for PIGF, comprising specifically binding to the receptor binding domain on the secondary PIGF isoform; (2) an antigen binding fragment produced by specific binding partner; (3) a procedure for the production of the specific binding partner comprising immunizing an experimental animal with primary or secondary binding or non-binding (free) PIGF-isoform; fusing the spleen cells of the experimental animal with myeloma cell, where an antibody-producing hybrid cells develops; cloning the hybrid cells and selecting the hybrid cloned cell that produces an antibody selectively, which bind the receptor-binding domain of the secondary PIGF isoform; (4) an immunoassay to detect PIGF in a sample comprising contacting specifically binding partner or antigen binding fragment with the sample; and determining the formation of immune complex under participation of the PIGF qualitatively or quantitatively; (5) a test kit for carrying out immunoassays comprising specific binding partner or the antigen-binding fragment; and (6) a use of antibody and protein of the family receptor-tyrosine kinase, homologous, fragment or degradation in assaying the binding of the PIGF isoform.
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