Use of the compounds derived from 3-alkyl-4-aryl-1,4,6,7,8,9-hexahydropyrazolo 4 ', 3': 5.6 pyran 2,3-b quinolin-5- amine as dual inhibitors of GSK3B - AChE and Nrf2 inducers for the treatment of neurodegenerative diseases

摘要

The present invention relates to the use of 3-alkyl-4-aryl-1,4,6,7,8,9-hexahydropyrazolo [4 ', 3': 5,6] pyran [2,3-b] derivatives quinolin-5-amine with dual inhibitory activity of the enzymes glycogen synthase-kinase 3 {be} and acetylcholinesterase, inducing capacity of the transcription factor Nrf2, and neuroprotective capacity. Another aspect of the invention relates to the use of the derivatives object of this invention for the treatment of diseases whose pathogenesis involves the abnormal activity of these enzymes together and / or oxidative stress and / or diseases that occur with deregulation of the activity. of phase II genes activated by the Nrf2 factor, such as neurodegenerative diseases.