Modulators of S1P receptors and their use

摘要

A compound selected from the group consisting of: ** Formula ** 2-amino-2- (5- (5- (3,4-diethoxyphenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2 -yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (3-chloro-4-isopropoxyphenyl) -1,2,4-oxadiazol-3-yl) benzofuran -2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (3-methoxy-4-propoxyphenyl) -1,2,4-oxadiazol-3-yl ) benzofuran-2-yl) propane-1,3-diol ** Formula ** 5- (3- (2- (2-amino-1,3-dihydroxypropan-2-yl) benzofuran-5-yl) -1 , 2,4-oxadiazol-5-yl) -2-ethoxybenzonitrile. ** Formula ** 2-amino-2- (5- (5- (4-propoxy-3- (trifluoromethyl) phenyl) -1,2, 4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (3-bromo-4-propoxyphenyl) -1, 2,4-Oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (3-methyl-4-propoxyphenyl)) - 1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (4-cyclohexylphenyl) -1, 2,4-Oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (4- (4- (diethylamino)) phenyl) -1 , 2,4-oxadiazol-3-yl) b enzyofuran-2-yl) propane-1,3-diol2-amino-2- (5- (5- (3- (cyclopropylmethyl) -4-ethoxyphenyl) -1,2,4-oxadiazol-3-yl) benzofuran- 2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (3- (cyclopropylmethyl) -4-methoxyphenyl) -1,2,4-oxadiazol-3- il) benzofuran-2-5 yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (4- (cyclopropylmethyl) phenyl) -1,2,4-oxadiazol- 3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (5-chloro-6-ethoxypyridin-3-yl) -1, 2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (5-chloro-6- (ethylamino) pyridin-3-yl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- ( 6- (diethylamino) pyridin-3-yl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5 - (5- (5-Chloro-6- (piperidin-1-yl) pyridin-3-yl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (6-propylpyridin-3-yl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3 -diol ** Formula ** 2-amino-2- (5- (5- (6-pentylpyridin-3-yl) -1.2 , 4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (1-butyl-1H-pyrazole-4- il) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (6-chloro-5- (5- ( 4-ethoxyphenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (7-isopropyl-5- (5 - (4-Propylphenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (6-chloro-5- (5- (6-propylpyridin-3-yl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- ( 5- (5- (5-propylpyridin-2-yl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2 - (7-methyl-5- (5- (4-propylphenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 20 2- amino-2- (7-ethyl-5- (5- (4-propylphenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (7- (2-methylprop-1-enyl) -5- (5- (4-propylphenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane- 1,3-diol ** Formula ** 5- (3- (2- (2-amino-1,3-dihydroxypropan-2-yl) -6-chlorobenzofuran -5-yl) -1,2,4-oxadiazol-5-yl) -2-ethoxybenzonitrile ** Formula ** 2-amino-2- (6-chloro-5- (5- (3-chloro-4- ethoxyphenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (3-chloro- 4-propoxyphenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol, ** Formula ** 2-amino-2- (5- (5- (4) -bromo-3-chlorophenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol, ** Formula ** 2-amino-2- (5- (5 - (3-Chloro-4- (thiophen-3-yl) phenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol, ** Formula ** 2 -amino-2- (5- (5- (4-propylphenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol, ** Formula ** 2- amino-2- (5- (5- (4-ethoxyphenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol, ** Formula ** 20 2- amino-2- (6-chloro-5- (5- (4-propylphenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol, ** Formula * * 2-amino-2- (5- (5- (3-nitro-4-propoxyphenyl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol, * * Formula ** 5- (3- (2- (2-amino-1,3-dihydroxypropan-2-yl) benzofuran-5-yl) -1,2,4-oxadiazol-5-yl) -2- Propoxybenzonitrile, ** Formula ** 2-amino-2- (5- (5- (2-ethylbenzofuran-5-yl) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1 , 3-diol ** Formula ** 2-amino-2- (5- (5- (2-methylbenzo [d] oxazol-5-yl) -1,2,4-oxadiazol-3-yl) benzofuran-2 -yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (quinoxalin-2-yl) -1,2,4-oxadiazol-3-yl) benzofuran-2 -yl) propane-1,3-diol ** Formula ** (E) -2-amino-2- (5- (5- (4-methylstyryl) -1,2,4-oxadiazol-3-yl) benzofuran -2-yl) propane-1,3-diol ** Formula ** (E) -2-amino-2- (5- (5- (oct-1-enyl) -1,2,4-oxadiazol-3 -il) benzofuran-2-yl) propane-1,3-diol ** Formula ** 2-amino-2- (5- (5- (2-ethyl-1H-benzo [d] imidazol-5-yl)) -1,2,4-oxadiazol-3-yl) benzofuran-2-yl) propane-1,3-diol.