Heterocyclic compounds as trpm8 channel antagonists and their uses (Machine-translation by Google Translate, not legally binding)

摘要

Heterocyclic compounds as antagonists of trpm8 channels and their uses. The invention relates to β-lactam derivatives, capable of blocking the activation of thermoreceptors, in particular trpm8 channels and their uses as therapeutic agents for the treatment of diseases of the respiratory system (cough, asthma, etc.), of the skin (pruritus, atopic dermatitis, allergenic, psoriasis, etc.), of the eye (dry eye and excessive tearing syndrome), derived from cancer chemotherapy (allodynia to cold), as well as cancer (melanoma, prostate, kidney, breast, pancreas, osteosarcoma, etc.), among others. (Machine-translation by Google Translate, not legally binding)