Procedures for the treatment of malaria, tuberculosis and MAC diseases

摘要

A compound for use in the treatment of a disease selected from malaria, a Mycobacterium avium complex, a Mycobacterium tuberculosis or a Nocardia infection in a patient, where the compound has the formula ** Formula ** or a pharmaceutically acceptable salt of the same, where: R10 is hydrogen; X is H; and Y is OR7; where R7 is a monosaccharide or disaccharide, alkyl, aryl, heteroaryl, acyl, or -C (O) -NR8R9, where R8 and R9 are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, aralkyl, alkylaryl , heteroalkyl, aryl, heteroaryl, alkoxy, dimethylaminoalkyl, acyl, sulfonyl, ureido and carbamoyl; or X and Y are taken together with the carbon to which they are fixed to form carbonyl; V is -C (O) -, -C ( = NR11) -, -CH (NR12, R13) -, or -N (R14) CH2-, where N (R14) is fixed to C-10 carbon; where R11 is hydroxy or alkoxy, R12 and R13 are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, aralkyl, alkylaryl, alkoxy, heteroalkyl, aryl, heteroaryl, dimethylaminoalkyl, acyl, sulfonyl, ureido and carbamoyl; R14 is hydrogen, hydroxy, alkyl, aralkyl, alkylaryl, alkoxy, heteroalkyl, aryl, heteroaryl, dimethylaminoalkyl, acyl, sulfonyl, ureido or carbamoyl; W is H, F, Cl, Br, I or OH; A is -CH2-, -C (O) -, -C (O) O-, -C (O) NH-, -S (O) 2-, -S (O) 2NH-, -C (O) NHS (O) 2-; B is - (CH2) n- where n is an integer between 0 and 10, or B is an unsaturated carbon chain of 2 to 10 carbons; and C is hydrogen, hydroxy, acyl, acyloxy, sulfonyl, ureido or carbamoyl, or optionally substituted C1-C12 alkyl, optionally substituted ar (C1-C12 alkyl), optionally substituted C1-C12 alkoxy, heteroalkyl, optionally substituted aryl or optionally heteroaryl replaced.