Human binding molecules capable of neutralizing influenza A virus of phylogenetic group 1 and phylogenetic group 2 and influenza B virus

摘要

An isolated antibody or an antigen-binding fragment thereof, capable of specifically binding an epitope in the stem region of the hemagglutinin (HA) protein of influenza A virus subtypes of phylogenetic group 1 and virus subtypes of influenza A of phylogenetic group 2, and capable of neutralizing at least one or more subtypes of influenza A virus of group 1, selected from the group consisting of influenza A viruses comprising HA of subtypes H1, H2, H5, H6, H8, H9 and H11, and at least one or more subtypes of influenza A virus from group 2, selected from the group consisting of influenza A viruses that comprise HA of subtypes H3, H4 , H7, and H10, characterized in that the antibody or antigen-binding fragment thereof is also capable of specifically binding to the hemagglutinin (HA) protein of subtypes of influenza B virus.